Melatonin is a hormone secreted by the pineal gland that regulates the sleep-wake cycle. Melatonin acts as an antioxidant directly as a radical scavenger and indirectly through the regulation of antioxidant enzymes, and its protection against cancer has been shown in cancer types such as breast cancer.
It is a subject that has been researched by scientific studies that cancer is less common in patients who experience blindness from an early age, and that this may be due to increased melatonin secretion. This situation has been studied mostly on breast cancer.
In our study, it is suggested that the protective effect of melatonin may also be effective in different types of cancer. For this reason, the effect of 3 different doses of melatonin applied on human brain cancer cells for 6 hours on cell viability and cell death was investigated in our project.